20 degree differential between two AoA data streams is huge.
There's no exact numbers- optimal angle of attack for an airfoil in any particular steady-state flight condition depends on aircraft weight/CG position, mach number, density altitude, and position on the wing. Position on the wing is interesting to keep in mind, because most aircraft wings are swept combinations of several, sometimes many, individual foil shapes and there is typically twist in the chord angle between the root and the tip of the wing; so the 'true' AOA is different at any given point on the wing. The reason for the airfoil twist in the wing is actually to control where stall conditions first arise on the wing to make the stall more progressive and easier to control/recover.
Anyway. Most conventional airfoil shapes will have a stall angle between 15 and 20 degrees, and actual operating aoa will be much lower, say 2-4 degrees.
So yeah, having two aoa streams, one telling you that the aoa is 2 degrees and the other saying it's 22 degrees is potentially really, really bad.