It is a good question, the design of sway frames is something that I had trouble with when I first started out because I couldn't find any resources that where appropriate for the design I was doing at the time.
Your example, you say that you assummed the bases are fixed. Can you prove that the foundations can resist moment, for an embedded pile, I would say the base is fixed but I wouldn't be making that assumption for a pad footing unless the footing can be shown to resist the moment at the base. Being a single span, you are designing edge columns so all the negative moment in the slab at the slab-column joint will need to be transferred into the column, so the stiffer the column is (eg. fixed base versus pinned base) the more moment it is going to attract at the slab-column joint.
You will need to perform an elastic analysis to determine what the end moments of your columns are. I will assume that you are only designing for vertical loads at the moment but be mindful that lateral forces may indeed require you to increase the amount of reinforcement in your column. To design for vertical loads I would assume that the column remains uncracked and use the gross I value for design (even though you may be able to prove that the column cracks, loses stiffness and redistributes moment back midspan).
You will also need to make a valid assumption for the stiffness of the slab. There is a section in the code that will enable you to make an estimate for the effective moment of inertia based on the ratio of the service moment to the cracking moment. Going through this calc you may find the effective inertia of the beam to somewhere between 0.4 to 0.6*Ig.
You will need to determine what is the governing load case in which the most moment is transferred into the column. Because the cantilever will counterbalance the span, I would apply live load to both the cantilever and the span in separate load cases to see which load case creates the greatest unbalanced moment to be transferred into the column with minimum axial force (closer to the pure bending point on the interaction diagram). Once you determining the end moments at the top and bottom of the column, you can run through the code clauses to find the moment magnifier (should be one because the columns are in double curvature) and then design the column using an interaction diagram.
Let us know if you are having any trouble. There was a good post recently about what Ieff to use for reinforced concrete so you might want to do a search for that. I can post a diagram with the showing what assumptions you should be making with regard to stiffness.