Kander,
Like the others say, there is a 22" Class 300 flange. But it's not covered by AMSE B16.5 (or even ANSI before the designation change)
This flange is covered by standard MSS-SP-44.
It's a common mistake that people think all flanges up to 24" are per B16.5. The 22" size isn't as you have found out.
I hope this helps.
NozzleTwister
Houston, Texas