Depending upon what fails, and how, there's no way to predict how big pieces can be, or how far they'll travel. If you have a massive failure, you'll be down for a while anyway, as the inspection authorities will very likely insist on carefully inspecting any undamaged boilers. The steam header, feedpumps, DA, stack, etc could all be damaged.
I've never heard of industrial boilers being spaced to allow for explosions. Usually, things get crammed in, as close as codes will permit to minimize building costs. If the steam source is considered very critical, then separate steam plants at each end of the production facility are the answer. This is very rare as well, since now you have to have two of everything.
A properly designed, installed, operated and maintained powerhouse will be safe and reliable. Build it right, and staff it with properly trained people who have the resources to do their jobs, and you won't have much to worry about.