Absolutely, positively NO RELIEF VALVE. Use a rupture disk ONLY! Can't emphasize this enough.
You must size the rupture disk yourself, no vendor will do it for you. However, contact Fike Corporation and get their catalogue. It shows you how to do it.
In a nutshell, you treat the rupture disk as any other piping component. The trick is to know which flow equation to use and the rupture disk's contribution to the overall system pressure drop. Talk to the vendor for the type of disk to use for your system and they will then be able to tell you the Kr value to use. Kr is similar to a K value you would use for a pipe fitting, e.g. tee connection, elbow, etc. Your unknown is what flow equation to use? Use whatever equation or algorithm you use in your plant when analyzing flow problems.
The size will depend on the total pressure drop in the system. You say you have a 2" line but you do not give enough information about your system. Is this for vessel protection or pipe protection? The point is, 2" may not be large enough to prevent your source from overpressure. For a vessel, assuming a non-fire case, you cannot exceed 10% greater than MAWP or design pressure. Therefore, your size will depend on the pressure you obtain during relief from your vessel to your discharge point. Don't forget to de-rate the flow through the rupture disk (per ASME). By this I mean, whatever your calculated relieving rate is, multiply it by 1.11 (divide by 0.9) before applying the flow equation.
Also, you say your "set" point is 100 psig. For a rupture disk, this is the bursting pressure but additional factors must be taken into account, e.g. the manufacturer's range. I wish I finished and published my paper on this very subject for you to read (soon to be found at
but in the meantime, talk to Fike. They can help you with the particulars. You just have to do the calculations.