Hmmmm. Good question.
Typicaly one wants to maintain some minimum overpressurization of building to minimize infiltration. In some cases, folks only consider keeping too cold, or too warm air from "leaking" into building. But in truth one is also concerned with infiltrating humidity and dust/dirt, and other things.
I've seen a number of schemes used. Including rather complicated methods of calculating makeup air requirements to account for losses due to exhaust fans running. ie Total up exhaust fan CFMs. Then add the amount (for instance, 10%)for fresh OA intake. Plus maybe a little extra just to be sure. And arrive at some fixed number of OA.
The above can work. But tends to work poorly.
Also, some schemes use exhaust/relief fan (associated with AHU)modulation based on some fixed number. ie relief fan speed lags supply fan speed by 10%. (And/or same control scheme applied to dampers. Relief damper modulated open based on fixed number which is a lag behind OA damper modulating open.)
Ditto, can work, but not well.
Problem with all the fixed number methods is it requires careful calculation. Assumes exact number of exhaust fans are on and that each is putting out rated CFM. Etc. Etc.
If extra exhausts are started up that were forgotten during initial calculations, or another exhaust fan added later. Building becomes negative.
If exhaust fan (sizeable one) is shut down due to lack of need, or it just plain fails, or it's belt is slipping, or whatever, building gets pressurized too much.
Not good either. You're wasting energy conditioning more OA intake than yah need. Plus doors blow open. Are hard to shut.
My preferred method, and the one that I've seen working best as it accounts for variations that're normal in most buildings. Is a separate control point connected to a building (zone) space static sensor. Two sensing legs on sensor. One sensing pressure in space served by AHU. The other leg tubed to some point outside the building walls. Controls compare the two. Modulate separate releif dampers/relief fan for building (zone)that're independent of AHU. Or, modulate relief fan and dampers tee'd off of return ducting of AHU.
As building pressure, relative to outside, goes up, relief dampers open farther, and at some point (in my experience, somewhere around 60 to 70%) of opening, relief fan starts and starts incremental climb in speed as needed to reduce building pressure. As building (zone) pressure drops, relief fans slows further and further. At some point determined by fan performance curve, or simply by trial and error observation, yah stop the fan. Then rely on relief dampers to control pressure. (Relief dampers lagging relief fan as regards to shutting down.)
Typically, for ordinary buildings, we try for a positive .05 inch pressure. Enough to prevent the "majority" of infiltraion. Tho it won't stop it on especially windy days.
In some installations, setpoint is different. ie We have a customer that's a medical equipment manufacturer with clean rooms, etc. They have their own very definite requirements. A fairly high overpressure for building in general. Plus even higher, incrementally so, in various clean rooms.
As regards CO2. Specs and control schemes I've seen simply monitor either individual room/space, or return air, and nothing is done if CO2 below certain point. Then as CO2 level hits set point, if it does, OA minimum air requirement is incremented, slowly, in an attempt to lower CO2 below set point plus deadband amount.
You say you're in Canada? I'm in Minnesota. If you're gonna use this sort of scheme, best to have pre-heat coil to knock chill out of OA air. Better yet, put in an ERU (energy recovery unit).
Sorry, can't tell yah a lot more. I'm not a system or building designer. Just a controls guy. I have done some design work, but not a lot. Good HVAC designer would know more of the specifics than I would. Most times I just get specs and requirements from designer for what needs to happen. Then I do my thing of designing control scheme that'll accomplish designer's goals.
It's my observation that HVAC system designers usually don't know all that much about specific equipment and controls. But, OTOH, I don't know that much about all the math, design criteria, buildings codes, etc that it takes to design a good system. That's why, in-house, in the company for whom I work, we have different guys doing these things.