There are some other aspects of turning a pressure vessel handling liquid and vapor into a swole up piece of liquid filled pipe.
Is your energy source capable of overpressuring the vessel? If so, does your relief capacity measure up to relieving liquid as opposed to vapor?
Is your vessel capable of withstanding the higher velocity of pressure waves generated in water as opposed to steam?
Is your control source or exit valve capable of introducing conditions of hydraulic hammer?
Will a sudden and unyielding liquid presure wave cause problems at the seams of the vessel.
Yes, you can run the vessel liquid full but what are the consequences of changing the process going to do to the vessels integrity?
Also, the process of producing water vapor means you form bubbles on the surface of your vessel. If not this one then somewhere upstream. If you fill the vessel you are looking at liquid full, these bubbles might start collapsing at the vessel wall and cause surface cracking.
Some things to ponder........