That's fine if you have ZERO noise and ZERO measurement error. If you do have noise or measurement errors, then the slopes you generate are going to be relatively meaningless.
If your data doesn't fall on a line, then I'm not sure what you're trying to accomplish. If your trying to interpolate or do a prediction, then you should be fitting to a polynomial or something similar to mitigate the noise impact.
If your data are on a line, then you should fit to a line to get the best data possible.
TTFN
FAQ731-376