As a general rule, you need to be very careful when fitting high-order polynomial curves of best fit, as they can duck and weave all over the place between your data points. And as for using them for extrapolation, be ultra-very careful. Personally, I shy away from using any polynomial higher than a cubic.
If you feel you need to resort to a high-order polynomial, your data might actually be telling you that a polynomial is not appropriate. You might be better off fitting some different form of curve - reciprocal, exponential, etc - or even a combination of these. The resulting curve fitting cannot be done automatically within Excel, but it is not difficult. By laying your data out in an appropriate manner you can set up a cell that contains the sum of the squares of the errors for any particular set of parameters for the hypothesized relationship. You can then use the Solver to search for the set of parameter values that minimizes this sum of the squares of the errors.
Also, look very hard at your data, and ask yourself if there are any a priori reasons for expecting any particular behaviours (such as asymptotes), even if these behaviours will not significantly manifest themselves within the range of your data points. If so, select a form of curve that honours these behaviours.
HTH