There are other more complex issues between the differences in threaded and flanged valves. Typically flanged valves are used for high pressure and temperature due to better sealing. There are too many unknowns with threaded valves, when I spec a SS valve I do not allow threads due to galling, I use only flanged or butt weld valves on hazardous fluids.
The pressure and temp rating of threaded and flanged valves are different. A threaded valve is rated on a different bases then flanged valves. A threded valve may have a rating of 2000psig WOG this means it is good to 2000 psi at 100deg F, the ratings for threaded valves are 800, 1450, 1000, 1500, 2000 and 4000 psig. I should also indicate that the WOG stands for Water Oil Gas service valves and is a standard relating to testing. Now as for flanged valves they follow the ASME B16.34 pressure temperture ratings for pipe flanges i.e. a class 150 A105 flange has a rating of 285 psi at 100 deg F (I think). To make the whole thing more complicated the ratings given for the valve body thickness or end connection ratings are usually based on ASME A16.34 and actually matbe misleading. At higher temperatures it is the seat and gasket material which will dictate the pressure temperture rating, as a rule of thumb if the temp is over 450F you best check the seat material rating. One last difference between the valve end types is the selection of the material of construction which may also vary for a given manufacture based on size. They may only sell a WCB body in the threaded model and only handle up to 2", but have a wide range of flanged valve materials in all sizes. This maybe an issue in selecting your vendor.
As for porting a full port valve has basically the same pressure drop as sch 40 pipe, a reduced port valve can have 5-7 times the pressure drop.