What material system are you using? Carbon/Epoxy? E-glass/Polyester? Is it a material system that might be contained in Mil-HNDBK-17?
If it is a unique material system with little or no data, you need to seriously consider a test program. Even if the data is a well-known material, but you are processing it differently (you are using VARTM where others have Autoclaved) or if you are processing using a facility with an unknown "track record", you may still need the test program.
I would comment that DMACX's procedure can probably still be used in your situation. There are many programs that will "smear" the properties of laminates so that you can use 3-D orthotropic elements. In your case, you may use 5 layers with the two outer and the center-most layers being thin. This would allow you to check the tensile stresses and shear stresses at what are generally the critical locations...just a thought.