You have to look at each loading condition and design for the worst case scenario (each wind direction and case will provide a different combination of load on the wall, load on the roof, and MWFRS loading). That said, it's typical to provide a strap for worst case uplift, nails for worst case lateral loads perpendicular to the wall, and blocking for worst case lateral loads from the roof diaphragm going down into the wall below. That will cover it in most houses. If you have an atypical connection situation or the number of fasteners exceeds what you can reasonably put into the connection, you have to look closer at each load case and design accordingly.