Paul,
Admittedly I haven't had a chance to finish reading your dense presentation yet, but here are a few of my initial thoughts.
1) It seems the concepts of size/MMC size, bilateral/unilateral tolerancing, and the envelope principle/rule#1 are conflated with geometric tolerances applied at MMC and the virtual condition generated from such a tolerance. These are separate, but not mutually exclusive, concepts and being precise about which one is being referred to or utilized is important.
2) I'm not sure I agree that "Product Development has lost sight of [interchangeable parts] as a design objective." Every Engineer and Designer wants parts to fit and assemble reliably and this is usually one of the top considerations, and if you're making more than one part thats design for interchangeability. I'd argue that this is one of the top considerations in creating and maintaining standards like Y14.5. In fact, I'd say the focus on ergonomics, ease of assembly, and throughput has only increased as the years go on - especially as factories turn to automation where high assembly forces don't just result in a complaint from assembly line workers but a rejection by a robot which is programmed to not exceed a certain maximum force, or damage by an indiscriminate robot with installation/applied forces that are too high.
3) The presentation seems to be focuses on MMC as the only way to achieve design goals. There are plenty of situations where RFS might be desirable or even required. Press fits come to mind where RFS actually best represents design intent, and certain controls like profile require RFS. MMC is often the most robust way to ensure assembly/design requirements and interchangeability, but its certainly not the only one. GD&T standards are often compared to toolboxes, they provide the tools to use and aren't necessarily there to tell you which ones to use.
4) You said ISO "doesn't have the tools for dimensioning for interchangeability" because the envelope requirement is not default? I'm no ISO expert, but can certainly be enforced with the Envelope symbol. Additionally the claim in ISO is that default enforcement actually can cause good parts to be rejected which is also true in ASME unless zero (insert geometric tolerance - typically position) @ MMC is utilized. There are also some nuances there due to the difference in the way size is evaluated in ISO vs ASME.
5) There is the claim that "there is no getting around the fact that there can be no tolerances added beyond that [rule#1 envelope of perfect form at MMC] or there becomes a conflict with this rock solid requirement." There are several exceptions to this rule even without the Independency symbol (I) which are right there in 2.7.1 after the portion you quoted - namely straightness, flatness, bars/stock, parts subject to free state variation (or more precisely when the free state modifier is used in Y14.5-2018), and one that it omits but it mentioned elsewhere (but is again mentioned in 2018) as when average diameter is used. I'm not sure how you can reconcile this with your claim.
6) Your definition of the MMC part as the ideal or "strongest" part ignores something as simple as assembly requirements - it would stand to reason that in most cases your "MMC part" would result in the highest installation forces and most difficult assembly (as well as highest imparted stresses due to press fit if that is the design condition). So on each end you have a less desirable condition depending on what you are considering, taking both into account a bias toward nominal could be considered most "desirable".
7) There are several references to the verbiage "true geometric form" contained in the standard. To my knowledge this isn't directly defined other than the context it is used in the quoted section, I haven't given it much thought till now but I would probably consider this in the same vein as True Profile. Not something that suggests "ideal" meaning "best" form, but that defines the "ideal" as in "theoretical" geometry of the feature.