Aaron - sometimes you need to use your judgment as to what you will tolerate.
I only use the Reject or Resubmit button when I believe either: (1) my marks are so significant that we will all be in trouble if they are missed, or (2) this contractor/detailer has no earthly idea what he's doing. In either case, you are rejecting with the intent to draw attention to the situation (as EZBuilding succinctly states).
I recently rejected a set of delegated design stair shops (exterior, covered) FOUR times. Eventually the general contractor forced the stair sub to go to a different provider. It was brutal and not covered in my fee, but since the "engineer" who stamped the calculations didn't understand load path, trib area, snow drift, design methodology, or assembly drawings, he had to go.
Other trades don't seem to be on the critical path like we are. Equipment guys ask for resubmittal all the time. When I ask for resubmittal I know it's probably holding up the job. I agree with the others who said that you need to let all interested parties know what's going on when you ask for resubmittal. You might also be able to ask for resubmittal "for record" (i.e. with no intent of return) without holding up the show.