More simple? Perhaps in appearance. In determination of a single unambiguous tolerance zone to which the feature(s) must conform? I would say not, especially when the requirements become tighter.
If you could have tightened up the positional tolerance in both directions to convert the bidirectional to a single tolerance, I would think one could creatively daisy-chain several single segment tolerances without specifying more than three datum features*. Though perhaps different tolerances in each direction reflects functional requirements, I would suspect that in fact it is the more restrictive of the two tolerances which would have the greatest impact on production/process limits - though of course function should drive specification I think theres something to be said of the unambiguous specification of requirements. If multiple interpretations are possible and/or the requirements for your inspection department are unclear, I would think that would have the possibility to be detrimental to function.
Bidirectional might still be possible with a similar method (I'd have to see the application), but certainly more cumbersome and with some slightly more complex results - though not nearly as complex and potentially problematic as trying to hold a tight tolerance with +/- directly toleranced position.
*though more could be utilized if necessary - actually increasing the potential stack up from the first bore to the last bore for an increase in complexity. This might be beneficial if one of the bores is held in position relative to the other - however if it is only "mutual position" which is of concern ie: position relative to each other without biasing DOF constraint to one or the other then the complexity of additional datum features is not necessary in my mind