The way I was taught in school was that components and cladding were used for elements loaded in a single direction such as roof deck, steel joists, and columns. MFWRS are to be applied to all members that take loads in two directions or more. This guidance is more a rule of thumb as all structural components should actually be checked for both all the time. The primary purpose of the components and cladding load cases are to capture the effect of the PEAK gust that only apply to small surface areas. In a hurricane the wind is not a uniform pressure. It has all kinds of small and large gust. So MFWRS loads are the average pressure applied to your lateral resisting system. Components and cladding are applied to small areas. So you don't mix and match the two as they represent different things unless you are doing so in a conservative way.
So for example lets take steel roof deck connections. You must actually design the deck connections for two different load cases.
For the components and cladding load case you design the deck and the deck connections for the uplift components and cladding load based on an area of less than 10 ft2. (span * span / 3)
Then you must also check the deck connections for MFWRS. Here you would check the deck for MFWRS uplift in combination with your diaprhagm shear (this checks the deck for overall effects of wind on the entire building. It is based on wind loads spread over the entire building envelope walls and roof) The deck at the boundaries must transfer the diaphragm shear to the shear walls similar to how a steel beam connects to a column with bolts. I find that the final line of welds often must have shear collectors which many engineers are failing to do. One puddle weld to a joist every five feet sometimes doesn't cut it. You can do two welds and often and that will work but then the joist seat must be designed for rollover.
Lets take timber truss connections now. Again there are two load cases. In one load case you have only uplift components and cladding force acting. When the wind hits the building your are checking that one truss that gets higher wind because a gust hit it and only it in isolation. The pressure depends again either on the tributary area of the truss or span * span /3.
A second components and cladding load case check would be the out of plane shear transfer from the wall. This is for high isolated gust hitting a wall. Again you check this in isolation. So if the connection of that one truss can tranfer that small gust area it is OK. It would be very unlikely that the same truss would handle both a high concentrated gust on the wall and the roof at the same time.
For the MFWRS load case you must combine both MFWRS uplift and MFWRS out of plane and MRWRS in plane pressures. This would be a correct methodology according to how I was taught and from everything I've read since. For trusses dumping diaphragm shear out of the deck into the shear walls or for trusses receiving shear from the walls being sucked or pushed on by wind this is a macro event. Kind of like the repetive member factor in wood design. All the trusses act in unison to transfer these lateral loads. Therefore you use the MFWRS shear loads in combination with the MFWRS roof laods.
In practice it takes time to come up with all these loads. I usually will combine the components and cladding loads and connect for that to be conservative. I will only usually seek out the MFWRS loads when checking combined loads if I'm really having trouble getting something to work at a reasonable cost. For example if I have to use multiple connectors or something really impracticle I'll sharpen the pencil and use the MFWRS loads in combination and the components and cladding loads in isolation. If you place shear collectors between the truss seats than you can completely eliminate the in plane diaprhagm shear transfer from the combination. Often I will pour concrete tie beams to support steel joist since you can get much stronger connections into concrete versus masonry.
So in summary you really must always check everything for both the components and cladding load case and the MFWRS load case. But by definition components and cladding is a singular load because its intent is to capture the effects a concentrated but high pressure gust that effects only a small area. When checking the MRWRS systems load path you must check the truss connections for shears in combination with uplift.
You will notice however that as areas increase the components and cladding pressures (for roof and walls) will approach the worst case MFWRS pressures. So again for saving time its usually practicle to work with the components and cladding loads for both your isolated checks and your combinded shear and uplift checks. If you get into trouble you can use the MFWRS loads as that is the intent of the codes. It can reduce your loads sometimes by 10 - 20% which can help when checking the combined shears and uplift.
Roof deck connections have become kind of a specialty of mine so I've become very intimate with ASCE 7-05, etc... I'm pretty darn certain what I've written above will never guide you wrong.
John Southard, M.S., P.E.