The engine sees three things, the 20 psi final boost pressure, some exhaust back pressure that it must work against to power the turbines, and some direct mechanical power loss to drive the supercharger.
If I was doing this myself, the first thing I would do is select a pair of turbos that will handle sufficient airflow at around half the expected final boost pressure. I would then fit either the largest a/r turbine covers available from the range, or the next largest. At least something a fair bit larger than mid size.
I would then eyeball the flow area inside the exhaust housings, and choose wastegates with about roughly the same flow area. This assumes that the turbos will hit full boost at about half redline rpm. At redline, roughly half the exhaust flow will be through the turbines, and half through the wastegates. This is a very simplistic assumption, but the wastegates will need to be fairly large, because the required flow will be high, and hopefully the exhaust back pressure driving that flow fairly low.
I would initially drive my supercharger to produce about one quarter to one third of the total final expected boost pressure, knowing that the turbo will increase that up to something approaching half the total boost pressure when everything else is hooked up.
If my engine was 454 CID, I would probably aim for about 6 psi theoretical supercharger boost to start off with. That is a pressure ratio of 1.4 In theory that is going to require 318 CID of air. If the blower displacement is 435 CID, then the blower needs to be underdriven at perhaps 0.73 crank speed. A 6-71 may be a more suitable size for twincharging if you have one, but I cannot say so for sure.
After that, it is just a case of testing what you have. See at what rpm the turbos spool up to full boost, and the relative boost contributions measured across both supercharger and turbo compressors. Adjust the supercharger drive ratio or the turbo exhaust housings to suit the application.
People doing this for the very first time almost always make the supercharger too large, and the turbos too small. Sizing both for a twincharge is nothing like sizing either to be used by itself on the same engine.
The supercharger will work much harder and generate more boost pressure across itself when assisted by the turbos. It can be made smaller, or significantly underdriven compared to what you would normally expect to run supercharged.
Likewise the turbo needs to be enormous on both the compressor and turbine side. Turbos compressors are rated at a pressure ratio of 2.0 A twincharge will run at high airflow and an unusually low pressure ratio, and the bottom of the flow map is not usually a friendly place way out in the choke region.
The same turbo on the same engine run without the supercharger might not see any boost at all below 7,000 rpm, it would be huge. But the supercharger will produce enough extra flow to lower the boost threshold, usually to about half what it would otherwise be.
Realise that the supercharger kicks the exhaust turbine with extra flow. And the turbo stuffs some extra dense air into the supercharger as it spools up. They assist each other in the most miraculous way. This results in a very fast boost buildup at rpm a lot lower than you might expect for such large turbos.
This all has to be experienced to be believed, but be conservative with supercharger sizing, and be very bold indeed with sizing the turbos, and it will all turn out about right.