Is the purpose survivability of the occupants, or having a lack of significant repair?
Paraphrasing: All wind is local. While there will be significant wind pushing and pulling on the main wind force resisting system, much of the damage starts as components fail in a progressive manner.
For survivability, 6 inch reinforced ICF walls with a CIP concrete ceiling/roof works quite well. If you don't want a (nearly) flat roof, you can use the concrete lid as an attic floor. Windows and residential doors are sacrificial under tornadic wind, as will be the cladding.
Having some strong interior walls (4 inch ICF, grouted CMU, plywood on stud) will reduce wind and debris from entering through failed windows. Be sure the partitions are sufficiently anchored.
There is limited good research on tornadic wind fields and houses. Unless you know how well something was built, and exactly what the wind was, you cannot correlate wind to damage sufficiently to get good design advice. Hurricane wind is much more easily correlated to destruction since the damage is typically less complete and the winds are more easily determined. Additionally, the risk of a single structure being hit by a tornado in its lifespan is infinitely small.
I am a proponent of taking reasonable measures, and my next house will be ICF and concrete roof, and the plans have sacrificial cladding and windows, and interior partitions which will protect occupants in sleeping rooms and other areas of refuge.