Yes,all defects and imperfections,grain coarsening etc ,gas porosity are normally related to thick section of the castings. There will be a variation in mechanical properties between those tested from standard test bars and those samples removed from thick section of the casting. If you are interested,perhaps I can look up and let you know.
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"It's better to die standing than live your whole life on the knees" by Peter Mayle in his book A Good Year