What needs to be known is what is the BEP of the pump, and how close to "shut-off" will the pump be running at the lower rates?
There are a lot of factors that need to be known before an answer can be supplied.
However, if you are installing a pump in a system that requires such variations in flow, I would look at installing a VFD, this is of course if you can operate it at lower heads as well.
Typically if the pump is running within the perameters of the pump curve, you are ok.
If you are running off the curve you are sure to experience problems.