The main difficulty is usually that operating pressure is almost impossible to be the same as MAWP due to the under tolerance of your relief valve.
A basic spring relief valve is often quoted at about 8%. Pilot operated can get you to within 3%, but then you also need to make 'space" for instrumented safety systems and alarms/ shutdown
AFAIK, there is no limit below MAWP you can set normal operating pressure as long as the MAWP isn't changed.
It's a bit strange and a bit of a waste of money, but if something else is causing the operating pressure to be set lower then so be it. Also in some cases it gives room for expansion / higher pressure or simply a facility starts at a higher operating pressure then it falls over time, especially for things like oil and gas fields.
Doesn't impact the MAWP and set pressure of a particular Pressure Vessel.
Remember - More details = better answers
Also: If you get a response it's polite to respond to it.