If the question is how many times a pressure retaining system may be pneumatically tested to 110% of its design pressure, the answer is as many as you like. There is no prohibition against the pneumatic testing of a component beyond a certain number of cycles to my knowledge, though I will be happy to stand corrected if someone can point to one.
Note that a leaking flange is not necessarily grounds for failure, as long as the flange seals at design pressure.