What type of press? I work with satmping presses, ease of die location, is a major factor. As is reliable recording of last settings. Small cahnges to the set are often required after a change of raw material, it is worth recording these changes so that they don't need to be found out again.
We dowel the top plate to the bolster, and use sprung loaded location spiggots from the top plate to the press ram. This means that the die is located within seconds and is always guaranteed to be square and central to the ram.
Lack of ancilary equipment / tools is usualy a major time consumer, where time is spent searching for kit. A well organised, well stocked area for tools, clamps, etc, will pay dividends.
Bladey.