haynewp,
The effect on the beams.
For rough stimating if you have a simple supported beam the moment in the mid of the span is (W*L^2)/8 and a bem fixed both end is (W*L^2)/10.
That's mean if you try to save on the end connection you have to increase for stresses or deflections (not shown).
The economy increase (small requeriments) if there is some continuity, the maximun economy is found arroud four or five continuos span, more span have no impact on the size of the beam.
The effect on columns.
Like redhead state, you are changing the slenderness factor of the column k, the column is more slender for that have less allowance stresses at the end.
The global behavior.
The columns fixed at ground and the beam simple supported at the columns. You have the more expensive structure, the stablity, deflection is just column responsability. The beam act like they are and have no economy.
The columns fixed at ground and the beams fixed to the columns. Is the most economical, taking advantage of the continuity for the beams. Unloading the columns ang giving some responsability for delection and stresses to beams. Your structure is located in this place.
Changing the restrains, and you go to an expensier structure more than the save for the changes. The posibility of reinforce the beam, or increase the size of the columns for the lateral movement control. The worse could be the change of member size (if the material if already bought).
Go for the safest way make an analisys with the changes, i normally use STAAD III 22.3WM this have an option for member end release partial moments.