TadB,
A long time ago before I knew what I was doing, I designed a sheet metal box out of 6061-T6. It did not work very well. The material is not suitable for bending because it is too brittle. I am not aware of problems drilling it, unless you are drilling through the area you weakened by bending.
Suggestions:
Do not bend the 6061-T6 extrusions. Purchase, or design and fabricate corner brackets, and assemble the your structure with nuts and bolts.
If you need rigidity rather than strength, consider 6061 without the heat treatment. This should be bendable. The T6 in the specification indicates heat treatment. Do not bother trying to tap holes in the stuff, as it is very soft.
The bendable aluminium is the 3000/5000 series, which is used for sheet metal. I do not think extrusions are available. Could you design your structure as an enclosed box?
Consider the fact that the mass, AND the elastic modulus of steel are three times that of aluminium. If you are building a truss structure loaded entirely in tension and compression, the steel structure will have the same weight and rigidity as the aluminium one. Due to the smaller cross sections, it will buckle at a lower load. Due to the fact that it is steel, everybody and his dog will know how to fabricate it.
JHG