The Ceramicspeed drive is a nice engineering adventure and a beautifully machined system of parts. But it does not have all the goods their Youtube videos indicate or intimate. Their representative is a smooth talker and has the script well memorized and he is proud of the product and the potential. The issues I see:
1. Shifting between gears is going to be difficult or impossible at high rotation speeds - hence, why none of their videos show gear shifting. They do explain a potential method of shifting using pre-machined shift channels and software/sensor control but as complication is added so is potential failure. The slightest bend/deformation of any of the driven cogs' teeth will send this system into total chaos/failure . . . (If there is a video showing actual at-speed shifting being done - I missed it and I will eat crow on this observation

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2. The claim of their system not being limited for gear ratios is misleading. True, additional cogged teeth could be added radially (out to the limit of the wheel radius) since the thickness of the cog cluster does not increase, but the driven cog wheel is a disk and as mass is added radially, the rotational inertia of the system increases. This will have to be a stiff, wear resistant material. Aluminium won't last and with grit and contact pressure, even steel or titanium, etc. will wear. Hmmm, mass applied at increasing radii - efficiency will be affected . . .
3. The final drive bearing "sprocket" will only stay engaged to the driven cog wheel if sufficient side load is applied to prevent the drive from skipping out of engagement. The stiffness of the driven cog wheel decreases as its radius increases. Thus, the drive will be very prone to skipping as the drive is moved to the larger radius locations (lower gear). Oh, and the drive bearing sprocket has rotating bearing drivers that geometrically do not want to stay engaged in their drive "pockets" because they are intrinsically trying to roll out/off the surface of the driven tooth. Only cross load/clamp pressure of the axle bearing set can hold these faces together. As clamp pressure increases so does the mechanical loss of the system. I suspect the gear position Ceramicspeed chose to use in their videos is the best working position on the whole prototype.
I'm a gearhead so I love beautiful machines and mechanisms, so my enthusiasm was raised when I saw the original post. But I got pulled back to earth after checking it out. I ride about 160 miles per week by bicycle, year-around, rain or shine and I will harp needlessly about the simplicity, ruggedness and efficiency of the chain derailleur system used on bicycles. Generally, the chain and sprocket system on bikes can be neglected completely and it will still get you where you want to go. An abused chain and sprocket system will make noise and efficiency will be reduced but can it transmit human power to forward motion of the bicycle? Yes. Reliably? Yes. Inexpensively? Yes.
I'll keep checking on the development of this drive to see where they can take it. I am a realist and I believe a wall of technical/material capability will doom the drive - some of the comments on the Youtube videos are expecting just throwing more money at the problems will solve them - the drive can be made from Unobtainium and it will be infinitely light, infinitely stiff/wear resistant and inexpensive. If only I could get a hold of some of that great material!