Tim,
Frame size only determines the physical size of the breaker (and thus limits its application range, lug size, etc...).
You can get different interrupting ratings within a given frame size.
Example: Square-D 250A frame class 520 comes in all standard trip ratings from 100A to 250A, all physically the same size, and each available with standard, intermediate, or high interrupting ratings.
Good on ya,
Goober Dave