Lilliput1--regardless of how the FH industry sells fume hoods they are not designed to be operated safely, vertically. In your example you describe the major problem with working vertically. When you lower the sash below the operators face--then how do workers see their hands when they are working 6" deep in the FH? This forces workers to make one of two choice--lower the sash until it doesn't block their line of site (which make it tougher to work the requried 6" deep) OR raise the sash until its' out of their line of site. Neither is an acceptable choice but its' generated by designing for reduced sash openings. As engineers we're not involved in ergonimic studies but this clearly one where we need to be involved and avoid these improperly thought out designs.
In terms of your design using 60-fpm full open or 100 fpm at 24", are you doing testing at both positions? You the design professional are required to specify the acceptable spillage and prove that any operating position meets the low spillage level you specify. If you specify a traditional 100-fpm fume hood then I guarantee a moderately challenging 110 evaluation will show it spilling like a pig (or higher than the arbitrary 0.1 ppm spillage 110 recommends) at the full open sash position. So when workers defeat the sash stop and raise it full open (as they do everywhere) then your safeties have been set aside and they will be exposed to whatever they are working on. Your liability doesn't end when the safeties are bypassed because of the requirement to test at full open. Some of the largest pharmaceuticals in the world are going horizontal only--and this is something we all should study.
In terms of the alarms this is another area where we engineers just simply must do a better job of evaluating the products. Virtually all fume hood alarms work with RTD or hot wire sensors capable of discerning between 0.1 to 0.05" WC. When you convert 100 fpm to Velocity pressure you find 100 fpm = 0.000623" WC. By AIHA-Z9.5-2003 we are required to annunciate a change in face velocity of +/-20% or 20 fpm = 0.000125" WC. Now we know that virtually none of our fume hood alarms are capable of actually providing the level of annunciation required. Secondly, using Vp=0.05 and solving for fpm=4005 x sq-rt (vp), fpm @ 0.05" = 896 fpm. So we need a change in face velocity of nearly 900 fpm for these alarms to get the change in pressure needed to annunciate.
We saw the same problem with Lab HVAC controls and that led to our firm abandoning them completely. There are two types of Lab controls used--Open loop or closed loop. The closed loop controllers acutally measure airflow in Vp, calcuate exhaust/supply CFM, and can modulate any damper to maintain a specific delta CFM. They fell out of favor over thermal and dirty air fouling the airflow sensors causing error. Open loop controls don't measure airflow but stoke dampers to a preset position--as an exmaple they track vertical sash height and modulate the exhaust damper to a position commensurate with 100 fpm at that sash height. The problems are many in that 100 fpm does not equal safety, vertical is less safe than horizontal and these systems have no way of tracking the preferred horizontal movement, and they cost far more than the limited benefits they purport to offer. If you don't measure airflow precisely then how can these systems purport to provide a very precise CFM -delta into a space. The answer is they cannot and do not.
In terms of the chilled beams ROSSABQ is right on. The 7.5W/sq-ft or 26 BTH/ft is right in line with the the 20-35 BTU/sq-ft we normally find (and far below the 40-60 btu/sq-ft many engineers default to). Using 30 btu/sq-ft and the 700 cfm example I used above this gives us a delta T of 8.5F, meaning this space would be in reheat 24/7 and we could not drop supply any lower without violating NFPA45 min FH exhaust. So beams would not be a good application for this room w/2-6' hoods. However, if we have 1-4' horizontal FH then we could provide a higher temp supply, the chilled beams can add to the cooling effect of the space, and the supply/exhaust can be hard balanced. The control sequence simply becomes a wall thermostat controlling a solenoid valve on the beams to augment room sensible cooling.
So we drive the 100% OA as low as possible. In rooms with high FH polulations beams are of no value. On the projects we've found beams (or any point of use heating/cooling devices) can be used in as much as 50-60% of the spaces. The end result is less 100% OA, more spaces with recirculated air (which is a basic tenant of Desinging Green Labs-Labs21), and less expensive and complex controls.
sorry for the epistolary.