I got MeX Linux (MeX 64 bit Linux (build 150714) based on Linux Mint 17.2 “Rafaela” with Cinnamon 2.6.13) persistence working, but it still takes many attempts to boot from a USB stick, and produces lots of error messages during the process, most related to the open source nouveau driver for my nvidia graphics card. The good news is that Draftsight installs without errors from the Ubuntu .deb file, survives a reboot, and seems to work so far.
The newer, 'better' version of Linux from the same author, called ExTiX 15.3 with LXQt 0.9.0 and kernel 4.1.0-3-exton, boots much more reliably, and the persistence works, but it absolutely refuses to install the Draftsight .deb file.
I tried that 'distro' because it allegedly comes with nvidia drivers installed by default, but attempts to adjust the nvidia settings produce messages that the nvidia drivers are not installed at all. Also, I like MeX' interface much better, but 'exton' alleges that the nVidia drivers don't get along with Gnome, so Gnome was replaced with LXQt.
The one 64 bit distribution for which I initially had hope is FatDog64, derived from Puppy Linux, which has a long history of working perfectly from USB sticks and multisession CDs with persistence, but FatDog's authors elected to build their own package manager, so FatDog can't use a .deb file or an .rpm file.
Such is the blessing, and the curse, of Linux. If you don't like it, wait ten minutes, and some random hobbyist will have released yet another new and improved version, that you may or may not like better, and which may or may not do anything useful, or anything at all.
You might want to install MeX and Draftsight on a USB stick while you still can. You'll need at least a 16Gb stick; 8Gb clearly isn't big enough.
Mike Halloran
Pembroke Pines, FL, USA