Isochronous stress-strain curves are a great tool in the right situation. You will generally get pretty good agreement between an isochronous stress-strain curve model and a time-explicit model if your creep law follows a simple von mises flow relationship between strain rate and equivalent stress, you aren't incuding any kind of damage model, your loads are proportional and monotonic, and your temperatures are uniform and constant. You might be able to handle some more complicated multiaxiality okay if you write your own flow rule for the plastic analysis.
You should run a few simple geometries with isochronous curves and the equivalent time-explicit model to get a feel for when they do well and when they don't. If you keep the element count low, you can do this pretty quickly. Koves and Zhao wrote a series of papers 10-odd years ago where they did this, and they also develop a technique for handling non-proportional loading with isochronous curves. Also check out Marriott's 2011 paper "Isochronous Stress/Strain Curves -- Origins, Scope and Applications." He says "Firstly, it should be stated that the isochronous curve approach is wrong" and then spends 7 pages discussing how useful they are. Also read his book with Penny, which covers reference stress methods extensively. Get the 2nd edition, which is heavily updated.
One thing to keep in mind with creep is that there is always a more detailed model and never enough data. You can get widely varying answers using different published approaches and data for geometry and loading that vary only slightly from those they were developed with. The best data is operating experience, so adhere to well established design rules whenever possible.
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