In general, and from the way you phrase your question, I take it you are not an experienced large bore pipe stress nor HVAC engineer, you cannot compare the established pipe stress (thermal expansion and pressure) analysis processes with the very thin wall, lightweight duct (HVAC) processes.
Pipe stress calc's (manual and computerized) assume high internal pressures , medium to very thick pipe walls, high fluid weights and high fluid temperatures. HVAC assume very low pressure gasses flowing at near-room temperatures, with "cooling capacity" flowrates and velocities and extremely thin pipe and sq duct walls. Flanges behave differently, anchors behave differently, and - although both are "round hollow things carrying fluids and gasses" - both behave very, very differently.
FEA is ill-suited for either analysis.