in interviews often are people that have nothing to do with the actual position (HR, anti-discrimination guy, union etc.). Most questions will be about your actual team work, general smartness etc. How you follow directions, etc. what you plan to do in 5 years (i.e. become a PE, go to graduate school).
Tell them what useful software you can use (not just MS Office) and ask what is their standard software. they won't expect you to be proficient in any software, but a general knowledge is good.
Of course they want to know what you learned what will help the job. there may be some token easy questions about technology, maybe some questions where they just want to see how you think and how creative you are.
You should learn about the company to show some interest.
Ask some questions that show you are interested in the company and the work. DON'T ask what benefits they have and how much vacation they offer etc. Ask if they give tuition assistance or any other training opportunities if they somehow come up to talk about benefits. Ask how they will train you (but without looking stupid like you need so much training). If you have multiple interviews you want to know which job to pick if you get offered multiple ones.
Don't lie. Obviously everyone makes himself look good, but don't make up things. They will figure it out. There is some wiggle room in describing how well you can use CAD etc. they are interested in someone being able to learn quickly. they also want you to be conform with their way of doing things. Sometimes it is better to train someone from the ground up the right way, than to deal with someone who is stubbornly doing it differently than being told because he learned it wrong some time ago.
In today's economy they probably get a good deal of applications from experienced engineers with years of experience. Your strength is the ability to learn they way better, to work for less money, and to be willing to work hard (apparently the ones that were laid off first, were the bad ones, so your competition might have an edge on experience, but you don't have that bad mark of being laid off)