We have an area where we have ten 100,000 gal interconnected reactors where we do a partial oxidation of cyclohexane with air. All ancillary piping for each reactor is considered in both PSV's and fire safety. The differentiation between each reactor was originally one isolation valve, but has been recently changed to 3. This was changed to minimize the inrush of reactants from the piping in the event of a vessel failure where the original single valve prevented the reactor from dumping. The deluge system is sized for the total volumetric loss of all fluids, vessels and lines.
I've been trying to find out which code or standard was used this area of our plant.
The big argument for several years was essentially the same question that you posted. It was resolved by the top man of the corporation who said account for every drop of Cyclohexane at all times.