TG,
Revolve a (closed) semi-circle to create your sphere, then use the Thinwall command to shell it. Remember to use DRIVING dimensions to control your Profile, otherwise you will have to re-enter the Profile environment and select the individual element any time you want to make a change.
To orient your ports, create a Coordinate System (UCS) for each port-axis required, then orient your Hole or Cutout using the 'Plane Normal to Curve' option and locking these to your Coordinate System(s) in turn.
REMEMBER to re-name your features in Feature Pathfinder (one of the panels in EdgeBar) for ease of navigation.
HTH,
Rick.