I hadn't heard of Proteus and a quick websearch indicates it is a schematic/PCB Layout/simulation package.
Most RF simulation is done with packages that are primarily designed for the issue of RF simulation. In RF most signal traces have to be considered as transmission lines and device parameters for input/output ports are analyzed as S parameters and with Smith Chart impedance's.
Most circuit simulation packages are all based on, or derived from the original Berkley spice which originated in 1973 written originally in FORTRAN and running on mainframe computers. Search SPICE on Wikipedia. They are excellent for analyzing analog and circuits built from resistance, capacitance, current sources, and voltage sources. Output is usually voltage or current Vs time. My guess is that Proteus is derived from the Berkley spice. If you want a low cost spice, download the free LT Spice from Linear Technology. LT Spice is also in its early origins derived from the Berkley Spice with the same basic commands, but had been extensively and continuously improved to the point of being an excellent and fast simulation package for modern personal PCs. Plus it is FREE with a large users group on Yahoo.
RF simulation quickly requires information outside of most data sheets like the Smith Chart plots of a transistor at a different bias level, which then requires a network analyzer to get the relevant information for a part. They you find your trying to put your function blocks together which then requires a load-pull analyzer setup and even more exotic equipment to get the information to make your simulation accurate enought.
Follow IRstuff advice. Buy a pre-made bluetooth headset, or buy a complete module which only requires an antenna, battery, and earpiece.
