Since you have already eliminated the best ways to get large files to load faster (better hardware: more RAM, faster processor), your choices are somewhat limited. Here's what I'd suggest.
First, freeze layers that you don't need to see while working on the file. For example, if the file is a topo map, freeze contours and spot elevations while working, and thaw them for plotting. This can greatly speed up load and regen times. You can use the Layer Manager commands in the AutoCAD bonus tools to save named layer configurations for plotting, etc.
You should consider using the xref command to reference the large file into a much smaller one for your work. You don't say what kind of files you are working with or what work you are doing, but this can make a real difference as well. Also, consider trimming and/or deleting entities from your file that you don't really need Just be sure to save the original version, just in case.
Good luck.