The problem is not necessarily with the self tappers. I've noticed, over the last number of years what I perceive to be a lot of inconsistancy in lower grade carbon steel pipe. (Pipe being what I work with for the most part.) We've hit chunks of pipe that we just couldn't cut a good thread in. We changed dies, cutting oil, different guys doing the threading. We still had torn threads. That is until we tried a different piece of pipe. Everything was fine then. We've been drilling holes for tubing supports on a machine frame, and hit spots on that assembly that were almost impossible to drill. Yet a few feet either side - no problem. New bits, same drill, same guy.
I can't prove it, but I think there's a lot of scrap/crap in much of the material that's on the market now, and that quality control at the mills is not nearly what it used to be. However, I don't necessarily blame the manufacturers. They provide exactly what the customer will pay for. As Pogo said: "We have met the enemy, and he is us."