lmike63,
The question whether the holes should be referenced to the same datums in the same order of precendence and in the particular sequence really depends on the function of a part.
If, as you are saying all holes are related, I would try with the same datum reference frame for all of them. As long as there is no functional need, the inclined hole (the one nominally perpendicular to D) does not have to be controlled relative to D at all.
Sorry if this is too general answer, but I would have to know at least how the part looks in bigger assembly to be more precise.