First, would it matter that most desuperheaters do not desuperheat right down to saturation? So you will always have 5-10-20° of superheat in your process steam (assuming your post-desuperheater runs are not so long so as to have enough temperature loss to get you down into saturation) depending upon your method of desuperheating.
Second, if you did your heat loss calculations based on a saturated condition, which infers the benefit of latent heat transfer on the steam side (and produces moisture I am sure you don't want in the piping) then you would be safer for the superheated portion of the piping, and would have to only deal with the driving force of the delta T of the superheated steam.
Sounds like the best of both worlds to me, unless, of course, there is a real possibility of getting into saturation.
rmw