A fluid mechanics class won't help.
A fluid mechanics degree wouldn't help either; it's not what it sounds like.
This is advanced engineered plumbing.
Buy the Crane book; it's not expensive. Don't lend it out; it has a habit of not coming back.
There's an Imperial version and a Metric version; buy whichever one suits you.
The book will eventually yield to study, and will give you techniques for estimating the pressure drop from end to end of one pipe.
Multiple pipes in parallel or series can be estimated using Kirchoff's Laws, which come from electrical engineering but work just fine for fluids, except that fluid resistors are square-law devices.
If you're using a centrifugal pump, you can't just pick a flow number out of a catalog.
You have to model the entire system for a guesstimated but completely arbitrary flow. Once you have a pressure drop for that arbitrary flow, you can use it to compute what is effectively a Cv, then use the Cv to plot the system resistance curve, and graphically find where the pump curve intersects it, which is the operating point for the pump. You can do a lot of it in Excel. The fancy tools just make a solution quicker.
Luckily for you, the typical mold cooling system is normally bled of air, so you won't have to worry about two-phase flow. Not so lucky for you, the typical mold cooling system has a fairly complex internal geometry. You can model it as a combination of orifices and pipes, but when you test your model against a real mold, it won't be super-accurate. I.e., you'll be doing well to get within a factor of 2 either way. Luckily for you, centrifugal pumps are not super fussy about that.
First buy the book, find the examples that apply to you, and work them.
Mike Halloran
Pembroke Pines, FL, USA