As a veteran designer, I don't tend to position the centerplane of a rectangular slot either. If the slot is horizontal, I am most commonly concerned about the bottom face. For a vertical slot, I look at the functionality/stack to see which side is more critical (there always is one). That's the reality of physical assembly & function as opposed to design function. In both those cases, a profile control is more functionally accurate than a position control. I would probably use a +/- width to control the second face.
In the case of a V-block, the centerplane is established by both faces. In your proposal, there is a tolerance on the 45deg +/- 30'. There is also a tolerance of +/- 30' on each face as it goes into the page [y]. So, the derived median plane (not actually a centerplane if you use symmetry) may still be dead center, but the mating part being aligned by the slot may now deviate to either side [x] by +/- 30' ... in reality, it WILL be at the extreme in [+xy] or [-xy] because the inspector will set it up to minimize rock. As a result, your mating part will not ever be properly oriented wrt the intended centerplane.
Profile controls (composite perhaps, to refine the relationship between the two inclined faces) controls the location and orientation (and form) of the two faces wrt the datums and wrt each other. It is an indirect control on the centerplane, but far more repeatable and controllable.
As for inspection, using 4-5 sets of opposed points on the inclined faces for a symmetry control ... well, that doesn't tell you what the entire face is doing, does it. For the profile controls, you put a feature simulator (true geometric counterpart) on each of the surfaces and probe off of the simulator, giving you an accurate reflection of the net effect of the entire feature.
Plus, symmetry really sucks.
Jim Sykes, P.Eng, GDTP-S
Profile Services
TecEase, Inc.