Thanks for the comment. The tubing, at different times, will see 60-80C fluid (similar to water in viscosity and density) at pressures between -7 and + 15 psig, and 80C vapor at pressures as low as 50 Torr (absolute). Oh, by the way, diameter is in the 1/2" range for the most part. I don't think permeability is a problem as it is not a deep vacuum application, nor is it sensitive to contamination/particles as in deep vacuum applications. There are going to be many short runs of this tubing (between valves, tees, etc). I want to stay away from the assembled hoses (like PFA lined with silicone over and SS braid and build in ends) as there are so many and it would add up to lots of cost. I have used PFA and/or FEP tubing in the past, either with PFA flare fittings (ultrapure) or SS compression - but never with vacuum, and am not sure of the vacuum rating at 80C with the material softened. I am guessing that I can just use a hard nylon (rated at 209" hg at 72F) over a metal barb. But I want to get experience and advice from others. Default, I think, is SS tubing and compression fittings. I am also asking the client if we can use copper (easier to bend) tubing with brass compression fittings).