Use your best judgement in finding the most restrictive path in your duct-work design (usually - but not always - your longest run). Calculate line by line friction and fitting losses from your unit to the most remote outlet. To confirm you selected the most restrictive run, compare other branches at the node where they connect. Only compare the branch in question from the connection point to its remote outlet to your original guess ... also from the connection point to the remote outlet. If the branch is more restrictive, it now is your new most restrictive path.
This most restrictive path ... everything is is balanced against and in proportion to it.
SMACNA Duct Design Guide has a good example problem in it.