Hi Mark,
Thanks for your feedback and additional info !
I presume by 'breather' you are referring to a component intended to vent fuel vapour to atmosphere as a result of thermal cycling ? If this is right - the fuel caps I designed always had the component associated with this function (normally a combination of non-return valve for rollover and low pressure valve for vapour escape) inside the cap - there was only one exception to this which was a 'capless' system, but this was abandoned recently by the OEM that was using it because its development was putting the project delivery at risk.
If you need to position the breather somewhere - the most obvious position is on somewhere that doesn't move - normally on something that goes across the car. I've personally seen some breathers mounted on subframes, wishbones - even one on the same reinforcer that the fuel filler pipe is bolted on. One position I have thought about trying though is somewhere on the wheelarch - the only reason I can think of not doing it would be that the fixing for the anchorage (if its a screw) could encroach on the package for tyre movement. One way round this might be a self adhesive fastening though ?
Doing away with the inner panel sounds a novel idea - cetainly would improve the performance of the fuel filler system but before you pursue it with effort - in my experience this mounting tends to be on a reinforcing panel for the rear quarter. Without this reinforcer - the cars I have worked on would always fail crash - either rear or side !!!
best wishes
sean