IreneAdler,
[ol]
[li]In an ideal joint, the screw is tightened very close to and even slightly over its proof stress such that an external load on the joint will affect the force between the clamped faces, only. The bolt will see constant force and stress. This eliminates any possibility that the bolt will fatigue.[/li]
[li]On a structural joint loaded in tension, the screws provide the least cross sectional area. All else being equal, the screws are the weak link in your design. If strength is critical, you need to maximize strength by, among other things, not bending the screws.[/li]
[li]In a highly stressed cantilever, you avoid stress raisers such as screw threads, especially at the fixed end where the high stresses are.[/li]
[/ol]
I am sure there are some other good reasons.
For a given application, any structure can be made big enough that it will not break. A cantilevered screw is not an efficient structure, but you can do the analysis and make it work.
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JHG