For a modern server room, the cooling load is equal to the equipment electricity consumption plus the normal building envelope gains.
If you take the IT equipment nameplate power rating, you can usually derate the total by a diversity factor of 0.8. However, careful in larger facilities that are running heavy calcs or using virtualization to consolidate multiple servers into one, as they often run a bit harder. A normal server will draw 70% of the nameplate just sitting there doing nothing.
There are a lot of best practices in the layout and design of services for critical facilities; ref: ASHRAE TC9.9 material, The Uptime Institute, Green Grid for Form, function, reliability and efficiency. If in doubt, call a critical facility professional. syska.com.