That's a common question that comes up with this sort of analysis case. How do you account for the effects of fastener/hole fits and/or clamping friction?
With a fastener pattern loaded in shear you might assume the fasteners have proper shear fits, and you would probably ignore the effects of friction. But if the fasteners have clearance fits, then you might assume the fasteners initially do not equally share the loads. And sometimes in certain applications the fasteners are designed to transfer all of the shear force through clamped friction produced by fastener preload. If the fasteners have clearance fits and are loaded in single shear, then bearing stress at the hole edges might also be a concern.
The analysis can be as simple or complex as the situation dictates. But simplified analysis approaches usually require more conservative factors of safety. The person asking the question mentioned that the analysis case they are actually considering is more complicated than what is shown in the sketch. So it might be helpful if more details were provided of the analysis requirements.