Maybe I'm not understanding the question.
In Table 4.4b of API-650, I see material G40.21-38W listed under Groups II, III, and IIIA in various forms, material G40.21-50W listed under Groups IV, IVA, and V.
If that's the material you're talking about, then you're substituting a Group IV plate for a Group II/III plate.
And that means the exemption temperatures, welding requirements, weld spacing requirements, stress relief requirements, etc. are different for those two different plates.
So you can't just swap them out willy-nilly without looking into the details.
I don't know what "cat 4" is, and don't know what the "wt" means if it's not the "W" plates listed above.