With regard to the initial question of engine placement, there is a simple thermodynamic question to be considered. Do you drag the airplane through the messy air that the prop makes, or do you drive the prop through the mess the airframe makes? It turns out that propellers, especially high powered ones, do not last long in the turbulent, buffeting airflow that often exists at thebackof an airplane during some flight segments. Nor do they survive ice shedding off the airframe for very long.
Consequently, you can't have open gear bay doors or wing flaps in the airstream ahead of a prop. Even if the prop lasts, the vibrations entering the drive train usually tear it up in time.
NASA research on laminar wings in propwash shows that the laminar flow is slightly disturbed in the region of the actual prop wake passage, but the overall drag increment is not large. Much of the laminar benefit is retained.
The Cessna push-pull twin, "Skymaster", is said to have noticeably better performance in cruise and climb when flying with the aft engine alone as compared to the forward engine only. First, note that this was an entry level twin and single-engine performance is only barely acceptable in either case; but, yes, it does a little better on the aft engine. Why? The blunt upsweep of the aft engine cowl has an impossibly high pressure recovery profile that the air cannot follow (i.e.,poor streamlining, which was done to avoid a long shaft). This causes considerable turbulence that causes high base drag when the aft prop is stopped; but with the aft prop actively pushing, the lower pressure ahead of the aft prop draws air smoothly around the cowl and eliminates most of the turbulence there.
The Skymaster does nothing to settle the question of which is best, fwd or aft props; because the bluntish aft body of the Skymaster is there only because of the aft prop. If the aft prop weren't there, the aft body would be faired to eliminate the base drag. A fair comparison would require that the airplane have a faired nose built for an aft prop performance test, and a faired aft body built for a fwd prop test. No one has done that.