Filtration may not be the only answer. You would have to capture vapor & dust at their point of emission using local hoods. Provide makeup air for exhaust. You may have to do solvent recovery on the exhaust to meet emission requirements.
You are asking for trouble with what you're describing. Volatiles should be used and handled in an approved fume hood. Otherwise, any spark will negate your filtering PDQ.
Your room sounds like a candidate for 100% outside air. IRstuff is correct about the fume hood, and presence of a fume hood in most cases requires that there be no return air from the room to the space.
This question appears overly broad to me. Before you decide what type of filters you need, you need to define what your requirements are. You need to consider what exactly is the "dust, gas, acetone" makeup that needs to be filtered. There is a lot of difference if the "dust" is ordinary dirt or if it includes grinding products from a toxic metal. Similarly, what type of gas?
You also need to determine how often people will be in the environment. If people are present all the time, then you have different needs then if people only go in once a month (maybe use air masks) or if you can purge the environment before they go in.
Finally, you need to determine the applicable regulations for your locality given the above. In the US, for example, the Environmental Protection Agency has a considerable interest in what is released to the environment.
Patricia Lougheed
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Depending on the contaminants gas phase filtration might be a solution. If you can get a clear idea of exactly what, and how much you're dealing with a combination of high efficiency filtration and gas-phase might be the way to go.
